CCBIO seminar – Marcus Buschbeck
Welcome to the CCBIO seminar series in the spring term of 2025. Open to all in auditorium 4, BBB. No registration necessary. Speaker is Marcus Buschbeck, Josep Carreras Leukaemia Research Institute, Barcelona, Spain.
Main content
Speaker: Marcus Buschbeck, Josep Carreras Leukaemia Research Institute, Barcelona, Spain.
Title: Mining the chromatin regulatory space for drug targets in myeloid malignancies
Host: Carina Strell, Mathias Ziegler
Place: Auditorium 4, BB-building
When: May 22, 2025 at 14.30-15.30
No registration necessary.
Abstract:
Epigenetic information is written in chromatin. But how exactly do epigenetic mechanisms operate at the molecular level? How does the environment influence these processes? How does nuclear metabolism impact chromatin structure and the cell’s epigenetic memory?
These are the questions we address in the lab. We combine basic research and applied research. In our basic research, we like to dissect molecular mechanisms of chromatin regulation and evaluate if this knowledge has an application in cancer. We have a long-standing interest in histone variants with macrodomains. In our more applied projects, we screen for novel drug targets for blood cancers and to understand their molecular mode of action. I will divide my talk into two halves and first present results showing how we identified CBP as sensitizer for azacytidine-based therapy. In the second part, I will present novel data that establish a histone variant as novel first-of-its-kind drug target in acute myeloid leukemia.
Keywords: histone variants, drug targets, combinatorial therapies, leukemia, 3D genome, chromatin regulation, myelodysplastic syndromes.
More information at: https://buschbecklab.org