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Gestational hypercholesterolemia and offspring cholesterol and modulation of cholesterol levels by dietary changes.

Even though the evidence of replacing saturated fat with polyunsaturated fat with regard to effect on plasma cholesterol level are extensive, still discussion and controversy exists, and the exact mechanisms as to how the saturated fatty acids increase plasma cholesterol levels remains to be completely understood.

Speaker: Prof Kirsten B Holven, head of Division for clinical nutrition, Department of Nutrition, University of Oslo, and head of research, National Advisory Unit on FH, Oslo University Hospital.

Increasing prevalence of obesity and sedentary lifestyle has resulted in an increase in number of young women of fertile age who have considerably elevated blood cholesterol levels during pregnancy. The Forsdahl-Barker hypothesis suggested, and was later confirmed, that the risk of CVD in adult life may be determined by an adverse environment during gestation. The in utero period has therefore emerged as a critical phase influencing disease risk for a range of disorders that develop later in life. However, while several studies have investigated the relation between maternal adiposity and dysglycemia and adult offspring cardiometabolic health, the relation between maternal dyslipidemia and offspring risk remains much less explored in humans.

Even though the evidence of replacing saturated fat with polyunsaturated fat with regard to effect on plasma cholesterol level are extensive, still discussion and controversy exists, and the exact mechanisms as to how the saturated fatty acids increase plasma cholesterol levels remains to be completely understood. Information about the molecular link between dietary fat quality and atherosclerosis is necessary both in order to prevent CVD but also to provide health authorities with evidence-based documentation for public advices.

 

Prof Kirsten B Holven is also the 1. oppnent in Linn Anja Slåke Vikøren disputas 26.02.2018, read more here.