Michael Sars Centre

Professor Nathalie Reuter, Dep. of Chemistry and Computational Biology Unit at UiB

Group Leader Nathalie Reuter from the Computational Biology Unit and Department of Chemistry at the University of Bergen will present her talk: "Dissecting peripheral protein-membrane interfaces".

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Scientific image
Image by Thibault Tubiana

Proteins’ functions are dependent on their structure and dynamics, two properties that do not easily let themselves observe directly from the lab bench. Powerful and enlightening alternatives are the methods of computational molecular modeling and simulations. Combined with protein bioinformatics to, for example, evaluate how general our findings are, we look at the structure-dynamics-function relationships, its conservation in families and its importance for membrane peripheral binding and enzyme activity, which is the main focus of our lab at the moment. 

We develop web tools such as WEBnma, for ENM-NMA, and PePrMInt, our new resource for the exploration of peripheral membrane proteins surfaces, and of their hydrophobic protrusions.