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The Shank family of proteins functions as a molecular scaffold in the neuronal post-synaptic density, enabling numerous protein-protein interactions. Shanks are large multi-domain molecules, and one of the conserved domains is an SH3 domain. Using high-resolution X-ray crystallography, we show that the SH3 domain in the Shank family has lost its canonical ligand-binding site.
The research group around Karl Johan Tronstad at the Department of Biomedicine has been granted 9.5 million to investigate the causes of chronic fatigue syndrome, or myalgic encephalopathy CFS/ME.