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The Department of Biomedicine

News archive for The Department of Biomedicine

N-terminal acetylation is a very common protein modification and NAA10 is the major responsible enzyme in human cells. Here we found a novel pathological NAA10 variant, NAA10 p. (R83H), in two boys with developmental delay and intellectual disabilities.
Arvid Lundervold from the Department of Biomedicine receives the award for best teacher at the Faculty of Medicine in 2018.
Two PNAS articles from the Arnesen lab are elected as the best publication of the year 2018 at the Faculty of Medicine. The prize will be awarded at the Faculty Day on 13 June 2019.
On May 23 and 24, 2019, the world's leading fibrosis and cancer researchers met in Bergen at an international fibrosis conference on the topic "New tools to study the fibrotic stroma".
The structure of full-length phenylalanine hydroxylase in complex with the cofactor BH4 is presented in the most recent issue of PNAS. As the cofactor is also used as a therapy for PKU, this structure is of medical importance.
As the first lab in Norway, the NAT lab recently installed a HoloMonitor system for 3D live cell microscopy. This novel instrument allows us to spy on the cells in a gentle and non-invasive way.
Researchers from the lab of Aurora Martinez describe a novel mechanism for the degradation of enzymes involved in phenylketonuria and other neurometabolic disorders.
In Huntingtons Disease, patients suffer from cognitive deficits and psychiatric disturbance, and later also from a devastating loss of movement control. Researchers at the Department of Biomedicine have identified some of the molecular events that occur in the brain in Huntingtons Disease.
Cancer is a complex disease caused by a multitude of factors gone wrong in the cell. NAA10 may be one such factor. This is a protein that performs many different tasks, including the most common which is catalyzing the acetylation of cellular proteins. NAA10 can therefore be viewed as a ”Jack of all trades”-protein. For two decades it has been linked to cancer progression, but recent data puts... Read more
Adrian Drazic, post doctor at the Department of Biomedicine, is one of the recipients of this years award for outstanding young researchers by the Meltzer Foundation.
Professor Rolf Bjerkvig at the research group for translational cancer research explains how the researchers make miniature brains and investigate how the cells move in and out of tumor tissue
In the elective subject ELMED219, father and son Lundervold give an introduction to the secret of artificial intelligence and how it can be used in clinical work.
Monica Hellesviks winning poster “NAA80 knockout cells: Fast and Furious?” scores with elegant simplicity and effective communication of scientific results.
There are over 100 tumor types only in the central nervous system. The Translational Cancer Research Group at the Department of Biomedicine provided data and material for a new diagnostic tool that will make it easier for cancer researchers to see the difference.
The enzyme tyrosine hydroxylase is essential for life. Neurological, psychiatric and cardiovascular disorders occur when its catalytic function is impaired. Researchers at the Department of Biomedicine describe how new insights into the protein might help develop new avenues for treatment.
Thomas Arnesen and Harald Barsnes from the Department of Biomedicine are part of a new european consortium in the field of mass spectrometry based proteomics research. The European Union has awarded 10 million Euro.

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