News archive for The Department of Biomedicine
Andrea's paper on the structure and cellular localization of malaria parasite actin II was accepted for publication in PLoS Pathogens today! The work was a huge long-term collaborative effort between our lab and the lab of Inga Sidén-Kiamos at IMBB-FORTH, Heraklion, Crete, and that of Peter Rosenthal at the Francis Crick Institute, London, UK.
Budding yeast is a useful model system in molecular biology. Here, researchers in Bergen and Ghent used it to define one of the most abundant protein modifications in eukaryotes: N-terminal acetylation.
After years of work, we finally can see what the apicomplexan glideosome-associated connector (GAC) really looks like! Check out our latest preprint presenting the structure in two drastically different conformations. Based on its structure, we suggest a role for GAC as an elastic spring helping parasite motility and invasion.
Ruth Brenk has given a brief update of the riboswitch research in our group at the Digital Breakfast organized by the the Center of Digital Life.
Andrea's work together with collaborators from IMBB-FORTH (Heraklion, Crete) and Francis Crick Institute (London, UK) on malaria parasite actin II is out in preprint form.
Post-doctoral (or graduate student) position in structural biology of parasite motility (23.10.2022)
We are looking for a post-doctoral fellow for a 2.5-year project (possible extension for up to 1 year) in my group at the Faculty of Biochemistry and Molecular Medicine (FBMM), University of Oulu, Finland. Alternatively, an exceptionally highly-qualified PhD student could be considered. The overall aim of my group is to understand the molecular mechanism of malaria parasite gliding motility. To... Read more
Henni's recent work on characterizing compounds interfering with the malaria parasite profilin-actin complex and actin dynamics is out as a preprint on bioRxiv. The project is part of a large collaboration led by Madeline Dans and Paul Gilson from the Burnet Institute, Melbourne, Australia.
Our manuscript on the smallest malaria parasite myosin, MyoB, was accepted for publication in the Journal of Biological Chemistry. Read here a summary of Isa's nice work on this so-far uncharacterized myosin, which is important for the parasite invasion of red blood cells.
On Thursday October 6th, Atta defended his PhD thesis entitled "Structural characterization of Toxoplasma gondii armadillo repeat only protein and purification of actins from apicomplexan parasites". As the opponent, we had the pleasure of hosting Dr. Young-Hwa Song from the University of Lübeck, Germany. Huge congratulations to Atta and many thanks to the opponent and everyone who participated... Read more
We have a new PhD thesis hanging out for public display in the Tree of Science at the FBMM, University of Oulu. On October 6th, Atta will defend his thesis "Structural characterization of Toxoplasma gondii armadillo repeat only protein and purification of actins from apicomplexan parasites". The opponent will be Dr. Young-Hwa Song from the University of Lübeck, Germany. We look forward to the... Read more
Today, Kalyani Mukherjee joined our group as a PhD student, funded by a stipend by the Sigrid Jusélius foundation.
Myelin is a crucial structure for the normal functioning of the vertebrate nervous system. Here, we have used multiple state-of-the-art technologies at large international research infrastructures, enabling methods not available in Norway, to obtain 3D structural information on some of the most hydrophobic protein molecules in the human body, which are responsible for the correct structure and... Read more
Nanobodies are single-domain fragments obtained from camelid antibodies, which have high affinity towards their target protein. Two recent publications describe the development and use of nanobodies directed against the neuronal Arc protein to promote both structure determination, imaging and detection, and functional studies.
On Wednesday June 1st, Isa defended her PhD at the University of Oulu. The opponent was Professor Alf Månsson from the Linnaeus University, Kalmar, Sweden. We all could enjoy an interesting dialogue on myosins and motility, and Isa rocked all the way. Thanks to everyone involved and huge congratulations to Dr. Isa Pires!
Isa's work on Plasmodium falciparum myosin B is out on the preprint server bioRxiv - just in time for her PhD defense. Hopefully soon in peer-reviewed form too.
This week, Jude Santhampillai joined our group in Oulu as an orientation student and will work for three weeks with Henni.
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