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The Department of Biomedicine

News archive for The Department of Biomedicine

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Improved understanding of oxygen sensors in human cells (26.11.2024)
Oxygen is vital for human life and so is our ability to respond to low oxygen levels. Researchers at the University of Oxford and University of Bergen have uncovered new factors defining how human cells respond to hypoxia.
ACS_Baumann2024
Histone Deacetylase Inhibitors Show Selective Inhibition of Aromatic Amino Acid Hydroxylases (15.11.2024)
Aromatic amino acid hydroxylases (AAAHs) like PAH, TH, and TPH are essential for producing key neurotransmitters and require iron and tetrahydrobiopterin to function. This study screened 307 histone deacetylase inhibitors and found that compounds like panobinostat can inhibit AAAHs at low micromolar concentrations, suggesting new therapeutic applications for these inhibitors.