News archive for The Department of Biomedicine

We have established a new method to use Positron emission tomography CT (PET CT) to evaluate Glomerular Filtration Rate (GFR) in rats. GFR is a pivotal parameter for kidney function. The traditional method to evaluate GFR is cumbersome with several time-points for blood and urine sampling. Imaging modalities are ideal to evaluate small animal kidney function due to the non-invasive and repeatable... Read more

N-terminal acetylation is a very common protein modification and NAA10 is the major responsible enzyme in human cells. Here we found a novel pathological NAA10 variant, NAA10 p. (R83H), in two boys with developmental delay and intellectual disabilities.

The structure of full-length phenylalanine hydroxylase in complex with the cofactor BH4 is presented in the most recent issue of PNAS. As the cofactor is also used as a therapy for PKU, this structure is of medical importance.

Cancer is a complex disease caused by a multitude of factors gone wrong in the cell. NAA10 may be one such factor. This is a protein that performs many different tasks, including the most common which is catalyzing the acetylation of cellular proteins. NAA10 can therefore be viewed as a ”Jack of all trades”-protein. For two decades it has been linked to cancer progression, but recent data puts... Read more

Attention-deficit/hyperactivity disorder and autoimmune diseases: etiological relationships and therapeutic possibilities

One long-standing question in myelin biochemistry was solved, as a new binding partner specific for the large isoform of MAG was identified.

The research laboratory for brain cancer immunology and therapy at the Department of Biomedicine has received the secretary general of the Brain-Tumour Society Rolf Ledal to discuss current and future research projects.

Visual processing in the retina