Most Significant Publications

2020:

Manuel Valiente, Amanda E.D. Van Swearingen, Carey K. Anders, Amos Bairoch, Adrienne Boire, Paula D. Bos, Diana M. Cittelly, Neta Erez, Gino B Ferraro, Dai Fukumura, Brunilde Gril, Meenhard Herlyn, Sheri L Holmen, Rakesh K. Jain, Johanna A Joyce, Mihaela Lorger, Joan Massague, Josh Neman, Nicola R Sibson, Patricia S. Steeg, Frits Thorsen, Leonie S Young, Damir Varešlija, Adina Vultur, Frances Weis-Garcia and Frank Winkler. Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines. Cancer Research. 2020 Jul 8. doi: 10.1158/0008-5472.CAN-20-0291.

Zhang X, Ding K, Ji J, Parajuli H, Aasen SN, Espedal H, Huang B, Chen A, Wang J, Li X, Thorsen F. Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosome membrane permeabilization. Am J Cancer Res 2020 Feb 1, 10(2)545-563.

2019:

Bernatz S, Ilina E, Devraj K, Harter PN, Mueller K, Kleber S, Braun Y, Penski C, Renner C, Halder R, Jennewein L, Solbach C, Thorsen F, Pestalozzi BC, Mischo A, Mittelbronn M. Impact of docetaxel on blood-brain barrier function and formation of breast cancer brain metastases.   J Exp & Clin Cancer Res 2019 Oct 29;38(1):434. doi:10.1186/s13046-019-1427-1.

Aasen SN, Espedal H, Holte CF, Keunen O, Karlsen TV, Tenstad O, Maherally Z, Miletic H, Hoang T, Eikeland AV, Baghirov H, Olberg DE, Pilkington GJ, Sarkar G, Jenkins R, Sundstrøm T, Bjerkvig R, Thorsen F. Improved drug delivery to experimental melanoma brain metastasis by peptide-mediated permeabiliztion of the blood-brain barrier. Mol Cancer Ther 2019  Aug 29. doi:10.1158/1535-7163.MCT-19-0160. 

Aasen SN, Parajuli H, Hoang T, Feng Z, Stokke K, Wang J, Roy K, Bjerkvig R, Knappskog S, Thorsen F. Effective treatment of metastatic melanoma by combining MAPK and PI3K signaling pathway inhibitors. Int J Mol Sci 20(17):4235, Aug 29, 2019. doi:10.3390/ijms20174235.

Sundstrøm T, Prestegarden L, Azuaje F, Røsland GV, Varughese JK, Aasen SN, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Inghem ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Bjerkvig R*, Thorsen F*. Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Comm 7:55, Apr 10, 2019. 

2018:

Baghirov H, Snipstad S, Sulheim E, Berg S, Hansen R, Thorsen F, Mørch Y, de Lange Davies C, Åslund ÅKO. Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. PLoS One, 13(1):e0191102, 2018. 

Zeiner PS, Zinke J, Kowalewski DJ, Bernatz S, Tichy J, Ronellenfitsch MW, Thorsen F, Berger A, Forster MT, Muller A, Steinbach JP, Beschorner R, Wischhusen J, Kvasnicka HM, Plate KH, Stefanovic S, Weide B, Mittelbronn M, Harter PN. CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival. Acta Neuropathol Comm 6:18,  2018.

2016:

Bevacizumab Prevents Brain Metastases Formation in Lung Adenocarcinoma. Ilhan-Mutlu A, Osswald M, Liao Y, Gömmel M, Reck M, Miles D, Mariani P, Gianni L, Lutiger B, Nendel V, Srock S, Perez-Moreno P, Thorsen F, von Baumgarten L, Preusser M, Wick W, Winkler F. Mol Cancer Ther. 2016 Apr;15(4):702-10.

2015:

A Novel Nanoprobe for Multimodal Imaging Is Effectively Incorporated into Human Melanoma Metastatic Cell Lines. Aasen SN, Pospisilova A, Eichler TW, Panek J, Hruby M, Stepanek P, Spriet E, Jirak D, Skaftnesmo KO, Thorsen F. Int J Mol Sci. 2015 Sep 8;16(9):21658-80.

Melanoma brain metastasis is independent of lactate dehydrogenase A expression. Sundstrøm T, Espedal H, Harter PN, Fasmer KE, Skaftnesmo KO, Horn S, Hodneland E, Mittelbronn M, Weide B, Beschorner R, Bender B, Rygh CB, Lund-Johansen M, Bjerkvig R, Thorsen F. Neuro Oncol. 2015 Oct;17(10):1374-85.

2014:

In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways. Daphu I, Horn S, Stieber D, Varughese JK, Spriet E, Dale HA, Skaftnesmo KO, Bjerkvig R, Thorsen F. Int J Mol Sci. 2014 May 16;15(5):8773-94.

A physiological perspective on the use of imaging to assess the in vivo delivery of therapeutics. Qin S, Fite BZ, Gagnon MK, Seo JW, Curry FR, Thorsen F, Ferrara KW. Ann Biomed Eng. 2014 Feb;42(2):280-98.

2013:

Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases. Thorsen F, Fite B, Mahakian LM, Seo JW, Qin S, Harrison V, Johnson S, Ingham E, Caskey C, Sundstrøm T, Meade TJ, Harter PN, Skaftnesmo KO, Ferrara KW. J Control Release. 2013 Dec 28;172(3):812-22.

Automated tracking of nanoparticle-labeled melanoma cells improves the predictive power of a brain metastasis model. Sundstrøm T, Daphu I, Wendelbo I, Hodneland E, Lundervold A, Immervoll H, Skaftnesmo KO, Babic M, Jendelova P, Sykova E, Lund-Johansen M, Bjerkvig R, Thorsen F. Cancer Res. 2013 Apr 15;73(8):2445-56.

In vivo animal models for studying brain metastasis: value and limitations. Daphu I, Sundstrøm T, Horn S, Huszthy PC, Niclou SP, Sakariassen PØ, Immervoll H, Miletic H, Bjerkvig R, Thorsen F. Clin Exp Metastasis. 2013 Jun;30(5):695-710.

2011:

A novel brain metastases model developed in immunodeficient rats closely mimics the growth of metastatic brain tumours in patients. Wang J, Daphu I, Pedersen PH, Miletic H, Hovland R, Mørk S, Bjerkvig R, Tiron C, McCormack E, Micklem D, Lorens JB, Immervoll H, Thorsen F. Neuropathol Appl Neurobiol. 2011 Feb;37(2):189-205.