Mitochondrial Medicine & Neurogenetics (MMN)

Laurence A Bindoff, MD, PhD

Professor & Consultant Neurologist

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Laurence Bindoff has a science (Biochemistry & Genetics) and medical training (specialising in Neurology) from the University of Newcastle, UK. He moved to Bergen in 1997, and took up a position as Professor in Neurology, Department of Clinical Medicine, University of Bergen, in 2001. As a neurological scientist, Laurence Bindoff has specialised in neurological genetics with special focus on mitochondrial diseases receiving his doctorate in mitochondrial disease from the University of Newcastle (Title: Defects of mitochondrial oxidations) with commendation.

His clinical activities focus on a specialised neuromuscular/neurogenetic service that sees patients with all types of inherited neurological disease albeit with particular focus on mitochondrial & muscle disease. He leads a research group of 5 including both PhD and post-doctoral fellows.



My main research focus is the investigation of mechanisms involved in mitochondrial disease. This includes identifying and studying mutations of the mitochondrial genome (mtDNA) and nuclear genes that cause mitochondrial dysfunction. One major focus of research at present is the diseases caused by POLG mutations, and this includes both patient based studies and the generation of a mouse model. In addition, we are studying mechanisms involved in ISCU myopathy and the processing of mitochondrial tRNA. Collaboration occurs locally with Medical Genetics & Molecular Medicine and internationally with groups in Italy, UK, and Finland.