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Translational Cell Signaling and Metabolism

News archive for Translational Cell Signaling and Metabolism

N-terminal acetylation is a very common protein modification and NAA10 is the major responsible enzyme in human cells. Here we found a novel pathological NAA10 variant, NAA10 p. (R83H), in two boys with developmental delay and intellectual disabilities.
Two PNAS articles from the Arnesen lab are elected as the best publication of the year 2018 at the Faculty of Medicine. The prize will be awarded at the Faculty Day on 13 June 2019.
As the first lab in Norway, the NAT lab recently installed a HoloMonitor system for 3D live cell microscopy. This novel instrument allows us to spy on the cells in a gentle and non-invasive way.
Adrian Drazic, post doctor at the Department of Biomedicine, is one of the recipients of this years award for outstanding young researchers by the Meltzer Foundation.
Monica Hellesviks winning poster “NAA80 knockout cells: Fast and Furious?” scores with elegant simplicity and effective communication of scientific results.
Thomas Arnesen and Harald Barsnes from the Department of Biomedicine are part of a new european consortium in the field of mass spectrometry based proteomics research. The European Union has awarded 10 million Euro.
Cinderella is a tale of being lifted from obscurity to recognition and significance. A review by young researchers at the Department of Biomedicine highlights the importance of the post-translational modifications of actin.
Read a summary of how researchers from UiB investigate new genetic variants associated with intellectual disability, autism spectrum disorder, and congenital abnomalies.
Researchers at the University of Florence had been looking for an new anti-cancer drug, when they realized the old rat poison called Vacor could be the answer to their searches
These researchers have made a sensational finding in cell biology. Adrian Drazic, Henriette Aksnes and Michaël Marie from Thomas Arnesen's group found an enzyme that others have been looking for for 30 years.
Researchers in TSG have, together with collaborators in Helsinki, identified a novel class of cyclic lipopeptides, named Anabaenolysin after the producing cyanobacterium, Anabaena. The lipopeptides have two glycines, two unusual amino acids, where one contains and a long unsaturated fatty acid chain. Their structures enable them to penetrate into membranes, but preferably membranes containing... Read more
Recently, researchers in TSG found that Ncp-M1 blocks the liver-specific transporter proteins OATP1B1/OATP1B3. These transporters are responsible for hepatocellular uptake of growth-stimulating steroids, several drugs, and toxins like microcystin, and are an important part of the detoxification machinery of the liver. Ncp-M1 is non-toxic to both liver cells and other cell types, and its mechanism... Read more
Stroke patients have particular high risk of thrombotic events caused by platelet (thrombocyte) activation, which may lead to new infarctions. Secondary treatment of these patients with anti-platelet therapy consisting of aspirin and dipyridamole is therefore a common protocol. Recent results on the mechanism of action of this treatment suggest that regulation of platelet shape change, the... Read more
Neuroblastoma cells are typically arrested at an early and immature stage. The stage of neuroblastoma tumor cell differentiation is known to influence patient outcome, with a high differentiation stage correlating to favorable prognosis.
The mechanisms of cancer cell drug resistance is still not fully understood.
The Translational Signaling Group has through professor Stein Ove Døskeland expanded our contribution of selected articles by "The Faculty of 1000". These publications are resulting from ongoing collaboration with research groups in Denmark and Germany.