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Translational Cell Signaling and Metabolism

Flluorescerende celler

The group focuses on basic principles of cell biology that are important for human diseases. We study cell signalling, protein modifications, and organelle function, and investigate how these affect the cell's metabolism and survival. We also study how these processes affect human diseases and how our knowledge can be used in the clinic.

The group is run by six principal investigators. Please visit our lab pages to learn more about our research.

Award
To forskningsartikkler stemplet med Best paper 2018

Paper of the year 2018

Two PNAS articles from the Arnesen lab are elected as the best publication of the year 2018 at the Faculty of Medicine. The prize will be awarded at the Faculty Day on 13 June 2019.

Science
Pills spilling

Killing cancer with rat poison?

Researchers at the University of Florence had been looking for an new anti-cancer drug, when they realized the old rat poison called Vacor could be the answer to their searches

New Research
Impaired function of the NAA10 R83H variant

A novel pathological variant of the acetyltransferase NAA10 causes disabilities

N-terminal acetylation is a very common protein modification and NAA10 is the major responsible enzyme in human cells. Here we found a novel pathological NAA10 variant, NAA10 p. (R83H), in two boys with developmental delay and intellectual disabilities.

Technology
Master student med laptop

Cellular espionage in the NAT cell lab

As the first lab in Norway, the NAT lab recently installed a HoloMonitor system for 3D live cell microscopy. This novel instrument allows us to spy on the cells in a gentle and non-invasive way.

New paper
NAA10 - A Jack-of-all-trades protein in human cells

A Jack of all Trades in Cancer Cells

Cancer is a complex disease caused by a multitude of factors gone wrong in the cell. NAA10 may be one such factor. This is a protein that performs many different tasks, including the most common which is catalyzing the acetylation of cellular proteins. NAA10 can therefore be viewed as a ”Jack of all...