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Translational Cell Signaling and Metabolism

Flluorescerende celler

The group focuses on basic principles of cell biology that are important for human diseases. We study cell signalling, protein modifications, and organelle function, and investigate how these affect the cell's metabolism and survival. We also study how these processes affect human diseases and how our knowledge can be used in the clinic.

The group is run by six principal investigators. Please visit our lab pages to learn more about our research.

Master’s degree
The image shows a stained cell with adhesion patches in red and actin cytoskeleton in yellow/white

TIRFing the Master’s degree to shore

Monica Hellesvik has been one of the pioneers to test the new TIRF microscope at the department. She needed to look closely at cell adhesive properties and the TIRF microscope was the perfect tool for it since it is particularly well suited for studying structures closest to the glass slides.

International research collaboration
Crystal structure of an enzyme. Background animal and plant shapes

Why evolution invented a paradoxical enzyme that eats up vitamin B3

Mathematical modeling and systems biology explain the evolutionary transition from a four-step to a two-step pathway for the synthesis of NAD from vitamin B3.

Award
To forskningsartikkler stemplet med Best paper 2018

Paper of the year 2018

Two PNAS articles from the Arnesen lab are elected as the best publication of the year 2018 at the Faculty of Medicine. The prize will be awarded at the Faculty Day on 13 June 2019.

Technology
Master student med laptop

Cellular espionage in the NAT cell lab

As the first lab in Norway, the NAT lab recently installed a HoloMonitor system for 3D live cell microscopy. This novel instrument allows us to spy on the cells in a gentle and non-invasive way.

New Research
Impaired function of the NAA10 R83H variant

A novel pathological variant of the acetyltransferase NAA10 causes disabilities

N-terminal acetylation is a very common protein modification and NAA10 is the major responsible enzyme in human cells. Here we found a novel pathological NAA10 variant, NAA10 p. (R83H), in two boys with developmental delay and intellectual disabilities.