The center wants to uncover causal mechanisms with relevance to prevention and clinic for non-communicable diseases. Individual researchers associated with the center work specifically with diseases of the central nervous system (neurodegenerative diseases, neurodevelopmental disorders, and brain cancer), but the center wants to develop projects based on the same approaches for other conditions for which the environment has expertise, such as other cancers, cardiovascular disease. birth-related conditions.
GlioLink, NEDCOM and DRONE are three central, partially funded, projects in the center. In these projects, we work to uncover causal mechanisms and new treatment principles for resp. glioblastoma, ADHD and autism, and several neurodegenerative diseases based on registry data, clinical data and experimental studies. Other important projects in / related to the center are…
The main purpose of the NEDCOM project is to identify patterns in and understand the causes of comorbidity in the neurodevelopmental disorders ADHD and autism in order to identify new possibilities for prevention and treatment. The project is based on linked data from national health registries and socioeconomic registries and uses epidemiological study designs, causal inference methodology and machine learning to identify patterns in co-morbidity between neurodevelopmental disorders and various psychiatric and somatic diseases, both among individuals and in individuals' families. Hypotheses generated in this work will be followed up to study underlying biological mechanisms and therapeutic possibilities. The follow-up studies will include studies of genetic risk factors in populations across established diagnostic categories and experimental laboratory studies. The function of proven risk genes will be mapped using various experimental systems, including cell models and animal studies. One will further systematically investigate possible pharmacological modification of proven risk genes and their gene products.