Prof. Nils Brose, Max Planck Institute for Multidisciplinary Sciences
Prof. Nils Brose, Director of the Department of Molecular Neurobiology at the Max Planck Institute for Multidisciplinary Sciences will present: "Dynamic regulation of presynaptic function and plasticity in health and disease"
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Nils Brose's research focuses on the molecular mechanisms of nerve cell development and synapse formation and function in the vertebrate central nervous system. To this end, Nils Brose's research group combines biochemical, morphological, mouse genetic, physiological, and behavioral methods to elucidate the molecular basis of nerve cell differentiation, synapse formation, transmitter release, and postsynaptic transmitter sensing. In several cases, they explore the dysfunction of corresponding biological processes in neuropsychiatric diseases. Their work in the field of nerve cell development focuses on the role of protein modifications by ubiquitin-like modifiers (SUMOs, Nedd8, Ufm1) in neuronal differentiation, their synaptogenesis research concentrates on synaptic cell adhesion proteins and their role in synapse formation and function, and their studies on the molecular mechanisms of neurotransmitter release focus on components of the presynaptic active zone and their regulatory function in synaptic vesicle fusion.
Visit Prof. Nils Brose's website.
