GUEST SEMINARS AT THE MICHAEL SARS CENTRE
Dr. Jeremy Dittman, Weill Cornell Medicine, USA
Dr. Jeremy Dittman, Associate Professor of Biochemistry at Weill Cornell Medicine, New York, USA, will present: "Molecular basis of synaptic vesicle fusion: new insights into Munc13 and Complexin function"
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Jeremy Dittman
The mechanisms underlying synaptic vesicle docking, priming, and fusion have remained long-standing mysteries in molecular neuroscience. Munc13 (an essential presynaptic protein) governs vesicle capture, SNARE assembly, and fusion while complexin maintains vesicles in a ready state by inhibiting spontaneous fusion. New structural and biochemical findings and analysis of human mutations have helped shape a more complete picture of the events preceding vesicle fusion and the regulation of synaptic transmission.
Seminar
13.08.2024 - 13.30–14.30
Sars Seminar Room. Thormøhlensgt. 55, 5006 Bergen
Photo:
Jeremy Dittman
29.07.2024