Molecular Imaging Center (MIC)

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  1. Balafkan N, Mostafavi M, Siller R, Liang KX, Sullivan G, Bindoff LA. A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates. Sci Rep 2020 Oct 28, 10(1):18498. Doi:10.1038/s41598-020-73656-2.
  2. Beigl TB, Hellesvik M, Saraste J, Arnesen T, Aksnes H. N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus. Exp Cell res 2020 May 15, 390(2):111961. doi:10.1016/j.yexcr.2020.111961.
  3. Engelsen AST, Wnuk-Lipinska K, Bougnad S, Vatter FAP, Tiron C, Villadsen R, Miyano M, Lotsberg ML, Madeleine N, Panahandeh P, Dhakal S, Tan TZ, Peters SD, Grøndal S, Aziz SM, Nord S, Herfindal L, Stampfer MR, Sørlie T, Brekken RA, Straume O, Halberg N, Gausdal G, Thiery JP, Akslen LA, Petersen OW, LaBarge M, Lorens JB. AXL is a driver of stemness in normal mammary gland and breast cancer. iScience 2020 Oct 7, 23(11):101649. doi:10.1016/j.isci.2020.101649.
  4. Fonnes T, Strand E, Fasmer KE, Berg HF, Espedal H, Sortland K, Stefansson I, Bjørge L, Haldorsen IS, Krakstad C, McCormack E. Near-infrared fluorescent imaging for monitoring of treatment response in endometrial carcinoma patient-derived xenograft models. Cancers (Basel) 2020 Feb 6, 12(2):370. doi:10.3390/cancers12020370.
  5. Ghila L, Bjørlykke Y, Legøy TA, Vethe H, Furuyama K, Chera S, Ræder H. Bioinformatics analyses of miRNA-mRNA signature during hiPSC differentiation towards insulin-producing cells upon HNF4a mutation. Biomedicines 2020 Jun 27, 8(7):179. doi:10.3990/biomedicines8070179.
  6. Herdlevær I, Kråkenes T, Schubert N, Vedeler CA. Localization of CDR2L and CDR2 in paraneoplastic cerebellar degeneration. Ann Clin Transl Neurol 2020 Nov, 7(11):2232-2242. doi:10.1002/acn3.51212.
  7. Hong Y, Liang X, Gilhus NE. AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study. Sci Rep 2020 Jul 8, 10(1):11230. doi:10.1038/s41598-020-68185-x.
  8. Islam T, Larsen Ø, Birkeland NK. A novel cold-adapted Methylovulum species, with a high C16:1w5c content, isolated from an arctic thermal spring in Spitsbergen. Microbes Environ 2020, 35(3):ME20044. Doi:10.1264/jsme2.ME20044.
  9. Jain S, Yassin MA, Fuoco T, Liu H, Mohamed-Ahmed S, Mustafa K, Finne-Wistrand A. Engineering 3D degradable, pliable scaffolds toward adipose tissue regeneration; optimized printability, simulations and surface modification. J Tissue Eng 2020 Sep 16, 11:2041731420954316. doi:10.1177/2041731420954316.
  10. Kleinmanns K, Bischof K, Anandan S, Popa M, Akslen LA, Fosse V, Gjertsen BT, Bjørge L, McCormack E. CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma. EBioMedicine 2020 Jun, 56:102782. doi:j.ebiom.2020.102782.
  11. Kleinmanns K, Fosse V, Davidson B, de Jalón EG, Tenstad O, Bjørge L, McCormack E. CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model. EBioMedicine 2020 Jun, 56:102783. doi:10.1016/j.ebiom.2020.102783.
  12. Legøy T, Ghila L, Vethe H, Abadpour S, Mathisen AF, Paulo JA, Scholz H, Raeder H, Chera S. In vivo hyperglycaemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiol (Oxf) 2020 Apr, 228(4):e13433. doi:10.1111/apha.13433.
  13. Legøy TA, Mathisen AF, Salim Z, Vethe H, Bjørlykke Y, Abadpour S, Paulo Z, Scholz H, Ræder H, Ghila L, Chera S. In vivo environment swiftly restricts human pancreatic progenitors toward mono-hormonal identity via a HNF1A/HNF4A mechanism. Front Cell Dev Biol 2020 Feb 25, 8:109. doi:10.3389/fcell.2020.00109.
  14. Legøy TA, Vethe H, Abadpour S, Strand BL, Scholz H, Paulo JA, Ræder H, Ghila L, Chera S. Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. Sci Rep 2020 Jan 15, 10(1):414. doi:10.1038/s41598-019-57305-x.
  15. Liang KX, Kristiansen CK, Mostafavi S, Vatne GH, Zantingh GA, Kianian A, Tzoulis C, Høyland LE, Ziegler M, Perez RM, Furriol J, Zhang Z, Balafkan N, Hong Y, Siller R, Sullivan GJ, Bindoff LA. Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations. EMBO Mol Med 2020 Oct 7, 12(10):e12146. doi:10.15252/emmm.202012146.
  16. Lotsberg ML, Wnuk-Lipinska K, Terry S, Tan TZ, Lu N, Trachsel-Moncho L, Røsland GV, Siraji MI, Hellesøy M, Rayford A, Jacobsen K, Ditzel HJ, Vintermyr KO, Bivona TG, Minna J, Brekken RA, Baguley B, Micklem D, Akslen LA, Gausdal G, Simonsen A, Thiery JP, Chouaib S, Lorens JB, Engelsen AST. AXL targeting abrogates autophagic flux and induces immunogenic cell death in drug-resistant cancer cells. J Thorac Oncol 2020 Jun, 15(6):973-999. doi:10.1016/j.tho.2020.01.015.
  17. Mahootchi E, Homaei SC, Kleppe R, Winge I, Hegvik TA, Megias-Perez R, Totland C, Mogavero F, Baumann A, Glennon JC, Miletic H, Kursula P, Haavik J. GADL1 is a multifunctional decarboxylase with tissue-specific roles in -alanine and carnosine production. Sci Adv. 2020 Jul 17;6(29):eabb3713. doi: 10.1126/sciadv.abb3713)
  18. Omsland M, Andresen V, Gullaksen SE, Ayuda-Durán P, Popa M, Hovland R, Brendehaug A, Enserink J, McCormack E, Gjertsen BT. Tyrosine kinase inhibitors and interferon-a increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines. FASEB J 2020 Mar, 34(3):3773-3791. doi:10.1096/fj.201802061RR.
  19. Pedersen L, Panahandeh P, Siraj M, Knappskog S, Lønning PE, Gordillo R, Scherer PE, Molven A, Teigen K, Halberg N. Golgi-localized PAQR4 mediates antiapoptotic ceramidase activity in breast cancer. Cancer Res 2020 Jun 1, 80(11):2163-2174. doi:10.1158/0008-5472.CAN-19-3177.
  20. Shanbhag S, Suliman S, Bolstad AI, Stavropoulos A, Mustafa K. Xeno-free spheroids of human gingiva-derived progenitor cells for bone tissue engineering. 2020 Aug 19, 8:968. doi:10.3389/fbioe.2020.00968.
  21. Varhaug KN, Kråkenes T, Alme MN, Vedeler CA, Bindoff LA. Mitochondrial complex IV is lost in neurons in the cuprizone mouse model. Mitochondrion 2020 Jan, 50:58-62. doi:10.1016/j.mito.2019.09.003.
  22. Xing Z, Cai J, Sun Y, Cao M, Li Y, Xue Y, Finne-Wistrand A, Mustafa K. Altered hydrophilicity on copolymer scaffolds stimulate the osteogenic differentiation of human mesenchymal stem cells. Polymers (Basel) 2020 Jun 29, 12(7):1453. doi:10.3390/polym12071453.
  23. Yamada S, Yassin MA, Weigel T, Schmitz T, Hansmann J, Mustafa K. Surface activation with oxygen plasma promotes osteogenesis with enhanced extracellular matrix formation in three-dimensional microporous scaffolds. J Biomed Mater Res A, 2021 Mar 5. doi:10.1002/jbm.a.37151.
  24. Zhang X, Ding K, Ji J, Parajuli H, Aasen SN, Espedal H, Huang B, Chen B, Wang J, Li X, Thorsen F. Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosomal membrane permeabilization. Am J Cancer Res 2020, 10(2):545-563.
  25. Åsrud KS, Bjørnstad R, Kopperud R, Pedersen L, van der Hoeven B, Karlsen TV, Rygh CB, Curry FR, Bakke M, Reed RK, Tenstad O, Døskeland SO. Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions. Acta Physiol (Oxf) 2020 May, 229(1):e13442. doi:10.1111/apha.13442.