Section for epidemiology and medical statistics

Haplin power analysis: a software module for power and sample size calculations in genetic association analyses of family triads and unrelated controls

We introduce a new and complete tool in the R package Haplin for power and sample size calculations in genetic association studies, readily applicable to data in MoBa or Harvest. The article is published in BMC Bioinformatics

Håkon Gjessing

Main content

The power calculations in Haplin can be performed for a wide range of genetic effects and etiologic scenarios, including child (offspring) effects, parent-of-origin effects and effects of maternal genes, as well as for gene-environment interactions. A variety of child-parent configurations can be used, including (but not limited to) the standard case-control design, case-parent triads, and case-parent triads in combination with unrelated control-parent triads. A power analysis demonstrates the possible scope of a study and is therefore useful for study planning as well as for the interpretation of findings in the final analyses. No prior experience with R is needed, and researchers can easily apply the Haplin functions using arguments and parameter values relevant to their own genetic data in MoBa or Harvest.