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Brenk lab

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Professor Ruth Brenk

The overall research goal of the Brenk lab is to improve methods used for structure-based drug design and to apply these methods to design inhibitors for enzymes with biological relevance. A key point in our research is the interplay of theoretical and experimental methods.

For more details, check out our research page.

Improving services of EU-Openscreen
Ribotacs

Funding for work on Ribotacs

As part of a consortium lead by the EU-Openscreen head office with the overall goal to improve the services offered by EU-Openscreen, the Brenk group has got funding to work on Ribotacs. Ribotacs are small molecules that selectively bind RNAs and a RNAse and thus lead targeted RNA degradation. We...

Drug discovery meeting
Ludvik Espeland presenting at the drug disocvery meeting.

Drug Discovery get together

In March, we had a Drug Discovery meeting to showcase the research that is going on Bergen and to connect the groups active in this area. Nearly 50 people had signed up of the meeting and we had 9 different talks covering topics from target discovery all the way to clinical trials.

Webinar at Research Days 2022

Towards the discovery of new antibiotics in the lab

Ruth Brenk has given a brief update of the riboswitch research in our group at the Digital Breakfast organized by the the Center of Digital Life.

Funding for large-scale interdisciplinary project
eHACS

Escaping the Combinatorial Explosion: Expert-Enhanced Heuristic Navigation of Chemical Space (eHACS)

Project funding from the NFR to carry out a collaborative project on expert-enhanced de novo design of small molecules.

All good things come in three
Photo by <a href="https://freeimages.com/photographer/Cjcj-40067">Chris Johnson</a> from <a href="https://freeimages.com">FreeImages</a>

Three more articles from the Brenk group in press

Read about druggabily predictions for RNA targets, the current state of fragment-based drug discovery for RNA, and an experimental toolbox to push drug discovery for antibiotics.

We offer topics for the degree MSc in the area of structure-based drug design, e.g. molecular modelling, fragment screening and X-ray crystallography. Don't hestitate to contact us for chat to discuss what exactly we can offer and how we can tailor this to match your  interests.

The Brenk Lab is part of the Biorecognition Research Group.