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Professor Ruth Brenk

The overall research goal of the Brenk lab is to improve methods used for structure-based drug design and to apply these methods to design inhibitors for enzymes with biological relevance. A key point in our research is the interplay of theoretical and experimental methods.

For more details, check out our research page.

Webinar at Research Days 2022

Towards the discovery of new antibiotics in the lab

Ruth has given a brief update of the riboswitch research in our group at the Digital Breakfast organized by the the Center of Digital Life.

Funding for large-scale interdisciplinary project
eHACS

Escaping the Combinatorial Explosion: Expert-Enhanced Heuristic Navigation of Chemical Space (eHACS)

Project funding from the NFR to carry out a collaborative project on expert-enhanced de novo design of small molecules.

All good things come in three
Photo by <a href="https://freeimages.com/photographer/Cjcj-40067">Chris Johnson</a> from <a href="https://freeimages.com">FreeImages</a>

Three more articles from the Brenk group in press

Read about druggabily predictions for RNA targets, the current state of fragment-based drug discovery for RNA, and an experimental toolbox to push drug discovery for antibiotics.

Review article
TOC graphic

Riboswitches as drug targets for antibiotics

Researchers at the Department of Biomedicine focus on large RNA structures in bacteria as a target for new antibiotics. Read the latest review article on riboswitches.

ISIDORe
ISIDORe

Fragment screening for pandemic prepardness

A large EU consortium got funding to integrated services for combatting current and future infectious disease outbreaks. BiSS is part of this consortium and offers fragment screening.

We offer topics for the degree MSc in the area of structure-based drug design, e.g. molecular modelling, fragment screening and X-ray crystallography. Don't hestitate to contact us for chat to discuss what exactly we can offer and how we can tailor this to match your  interests.

The Brenk Lab is part of the Biorecognition Research Group.