Ziegler lab

Compartmentalization of NAD

Most biological processes require energy and are tightly regulated. Energy is extracted from food supplies and eventually transformed into ATP, the universal energy carrier of the cell. These pathways consist of many reactions which involve NAD or NADP, small molecules which serve as intermediate energy transmitters.

Vitamin B3 is essential for the synthesis of these nucleotides. Interestingly, the key molecules in energy transduction also have important roles in the regulation of all vital cellular activities. While this has long been known for ATP, the multiple signalling functions of NAD and its derivatives have only over the past decade been fully appreciated. Research in many laboratories has now revealed several unexpected biochemical conversions of these nucleotides which might even have an impact on the organism as a whole, for example, life-span regulation.

News | Research
Marc Niere og Mathias Ziegler

Discovered a shuttle that brings the "batteries" into the cell's power houses

Researchers at the University of Bergen have made a major contribution to the discovery of a protein that plays a fundamental role in human energy metabolism.

International research collaboration
Crystal structure of an enzyme. Background animal and plant shapes

Why evolution invented a paradoxical enzyme that eats up vitamin B3

Mathematical modeling and systems biology explain the evolutionary transition from a four-step to a two-step pathway for the synthesis of NAD from vitamin B3.

Pills spilling

Killing cancer with rat poison?

Researchers at the University of Florence had been looking for an new anti-cancer drug, when they realized the old rat poison called Vacor could be the answer to their searches

Portrett av Mathias Ziegler

Principal Investigator: Mathias Ziegler (personal page)