BBB seminar: Marcel Dinger
Journeys through space and time: Ultra high-resolution expression profiling of long noncoding RNAs
Genomics and Epigenetics Division, Garvan Institute of Medical Research and St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia
Long noncoding RNAs (lncRNAs) are increasingly recognized as having key regulatory roles in development and disease. However, these regulatory molecules often have short half-lives and are expressed only in specific tissues or cell types, resulting in the poor representation of lncRNAs in transcriptomic datasets. Using novel detection and sampling approaches, we reveal a high-resolution spatiotemporal view of the long noncoding transcriptome that challenges existing paradigms of genome function and provides fresh insights into their roles in development and disease.
Chairperson: Karin Wibrand, Dept. of Biomedicine