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University of Bergen
Department of Clinical Medicine

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Forskergruppe for mitokondrie medisin og nevrogenetikk (MMN)

Gruppens forskning er fokusert på feltet nevrogenetikk (arvelige nevrologiske sykdommer) og vanlige bevegelsesforstyrrelser og nevrodegenerative sykdommer som dystoni og Parkinsons sykdom.

Dopamine transporter (DAT) imaging shows the uptake of a radioactive tracer...
Dopamine transporter (DAT) imaging shows the uptake of a radioactive tracer in the nigrostriatal terminals (bright areas). This reflects the integrity and density of the dopaminergic neurons in the substantia nigra. Patients with POLG mutations (C) have severe nigrostriatal degeneration, which is more pronounced than even in patients with Parkinson's disease (B). The scan of a healthy person (A) is shown for comparison. Tzoulis et al., Brain 2013.

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Les mer på gruppens engelske websider.

Cartoon depicting the structure of the pol-γ holoenzyme. The catalytic...
Cartoon depicting the structure of the pol-γ holoenzyme. The catalytic subunit (pol-γA) is blue and the accessory subunits (pol-γB) green and pink (pdb 3IKM, Lee at al., 2009).
07.02.2014