CCBIO Seminar – Sushma-Nagaraja Grellscheid

Speaker: Sushma-Nagaraja Grellscheid, Associate Professor at the Department of Biological Sciences (BIO), University of Bergen.

Title: Understanding alternative splicing regulation in health and disease

When: Thursday September 5th at 14:30

Place: Auditorium 4, BB-building

Chairperson: Agnete Engelsen

All are welcome, also to the following pizza get-together! No registration needed.

Abstract: 

We study the regulation of gene expression, especially RNA alternative splicing, in development, ageing and disease. Mutations in splicing factors are responsible for genetic diseases (such as retinitis pigmentosa), their levels change dramatically with ageing and senescence, and splicing factor levels are highly dysregulated in cancer. The target genes of this dysregulation are often unknown and represent an important but poorly understood class of biomarkers.

We employ a combination of wet-lab and informatics approaches using RNAseq and CLIP-seq to interrogate the regulatory networks controlling gene expression from transcription through to RNA processing.

This seminar will provide a broad introduction to the field, covering our past contributions, and our current projects, on alternative splicing regulation and disease.

The CCBIO Seminar series fulfills several aims.

• Firstly, it conveys relevant biomarker research to the local scientific community and students and younger researchers in particular, providing the ground for future recruitment.
• Secondly, it is part of two formal courses, BMED 380 on the master level, and together with the CCBIO Annual Symposium, forms CCBIO 902, a PhD level course.
• Last, but not least, the CCBIO seminars with their subsequent open pizza get-together are an important arena for informal interaction between international researchers, CCBIO PIs and other CCBIO staff as well as interested researchers and students in general.

All interested researchers, students and others are welcome!