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Åsmund Kaupang's picture

Åsmund Kaupang

Researcher
  • E-mailAsmund.Kaupang@uib.no
  • Visitor Address
    Realfagbygget, Allégt. 41
  • Postal Address
    Postboks 7803
    5020 BERGEN
Selected publications
  • Kaupang, Åsmund; Hildonen, Siri; Halvorsen, Trine Grønhaug; Mortén, Magnus; Vik, Anders; Hansen, Trond Vidar. 2015. Investigations on the covalent antagonistic modulation of PPARβ/δ.
  • Kaupang, Åsmund; Kase, Eili Tranheim; Vo, Cecilie Xuan Trang; Amundsen, Marthe; Vik, Anders; Hansen, Trond Vidar. 2016. Synthesis of 5-trifluoromethyl-2-sulfonylpyridine PPARβ/δ antagonists: Effects on the affinity and selectivity towards PPARβ/δ. Bioorganic & Medicinal Chemistry. 24: 247-260. doi: 10.1016/j.bmc.2015.12.012
  • Kaupang, Åsmund; Hildonen, Siri; Halvorsen, Trine Grønhaug; Mortén, Magnus; Vik, Anders; Hansen, Trond Vidar. 2015. Involvement of covalent interactions in the mode of action of PPARβ/δ antagonists. RSC Advances. 5: 76483-76490. doi: 10.1039/c5ra15707b
  • Gorbitz, Carl Henrik; Bonge-Hansen, Tore; Kaupang, Åsmund. 2013. N,N'-Bis(2-diazoacetyl)piperazine. Acta Crystallographica Section E: Structure Reports Online. 69: o1241. doi: 10.1107/S1600536813018801
  • Kaupang, Åsmund; Paulsen, Steinar Martin; Steindal, Calin Constantin; Ravna, Aina Westrheim; Sylte, Ingebrigt; Halvorsen, Trine Grønhaug; Thoresen, G. Hege; Hansen, Trond Vidar. 2015. Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618. European Journal of Medicinal Chemistry. 94: 229-236. doi: 10.1016/j.ejmech.2015.03.006
  • Kaupang, Åsmund; Gorbitz, Carl Henrik; Bonge-Hansen, Tore. 2013. A solid-state oxidation of 1,1,3,3-tetramethylguanidinium 4-methylbenzenesulfinate to 1,1,3,3-tetramethylguanidinium 4-methylbenzenesulfonate. Acta Crystallographica Section C: Crystal Structure Communications. 69: 778-+. doi: 10.1107/S0108270113015011
  • Kaupang, Åsmund; Bonge-Hansen, Tore. 2013. α-Bromodiazoacetamides – a new class of diazo compounds for catalyst-free, ambient temperature intramolecular C–H insertion reactions. Beilstein Journal of Organic Chemistry. 9: 1407-1413. doi: 10.3762/bjoc.9.157
  • Kaupang, Åsmund; Laitinen, Tuomo; Vik, Anders; Poso, Antti; Hansen, Trond Vidar. 2013. Molecular modelling and synthesis of putative high-affinity inhibitors of hPPARδ.
  • Kaupang, Åsmund; Laitinen, Tuomo; Poso, Antti; Hansen, Trond Vidar. 2013. Vibrational fingerprinting of hPPARγ in complex with ligands – application to the natural product (-)-mucosin.
  • Kaupang, Åsmund; Gorbitz, Carl Henrik; Hansen, Tore. 2011. 2-Diazo-1-(1,1-dioxothiomorpholin-4-yl)ethanone. Acta Crystallographica Section E: Structure Reports Online. 67: O1844-U2037. doi: 10.1107/S1600536811023774
  • Kaupang, Åsmund; Bolsones, M; Gamadeku, T; Hansen, Tore; Hennum, MJ; Gorbitz, Carl Henrik. 2008. 2SR,3RS)-Benzyl[4-chloro-1-(4-chlorophenyl)-1-methoxycarbonyl-2-butyl]ammonium chloride. Acta Crystallographica Section E: Structure Reports Online. 64: O2038-U4798. doi: 10.1107/S1600536808030742
  • Kaupang, Åsmund; Gorbitz, Carl Henrik; Hansen, Tore. 2010. tert-Butyl 4-(2-diazoacetyl)piperazine-1-carboxylate. Acta Crystallographica Section E: Structure Reports Online. 66: O2199-U467. doi: 10.1107/S1600536810016211
  • Kaupang, Åsmund; Hansen, Trond Vidar. 2020. The PPAR Ω Pocket: Renewed Opportunities for Drug Development. 21 pages.
  • Kaupang, Åsmund; Laitinen, Tuomo; Poso, Antti; Hansen, Trond Vidar. 2017. Structural review of PPARγ in complex with ligands: Cartesian- and dihedral angle principal component analyses of X-ray crystallographic data. Proteins: Structure, Function, and Bioinformatics. 1684-1698.
  • Kaupang, Åsmund; Kase, Eili Tranheim; Vo, Cecilie Xuan Trang; Amundsen, Marthe; Vik, Anders; Hansen, Trond Vidar. 2016. Synthesis of 5-trifluoromethyl-2-sulfonylpyridine PPARβ/δ antagonists: Effects on the affinity and selectivity towards PPARβ/δ. Bioorganic & Medicinal Chemistry. 247-260.
  • Kaupang, Åsmund. 2016. Development of PPAR Modulators and Investigations on their Mode of Action.
  • Kaupang, Åsmund; Paulsen, Steinar Martin; Steindal, Calin Constantin; Ravna, Aina Westrheim; Sylte, Ingebrigt; Halvorsen, Trine Grønhaug; Thoresen, G. Hege; Hansen, Trond Vidar. 2015. Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618. European Journal of Medicinal Chemistry. 229-236.
  • Kaupang, Åsmund; Hildonen, Siri; Halvorsen, Trine Grønhaug; Mortén, Magnus; Vik, Anders; Hansen, Trond Vidar. 2015. Involvement of covalent interactions in the mode of action of PPARβ/δ antagonists. RSC Advances. 76483-76490.
  • Kaupang, Åsmund; Hildonen, Siri; Halvorsen, Trine Grønhaug; Mortén, Magnus; Vik, Anders; Hansen, Trond Vidar. 2015. Investigations on the covalent antagonistic modulation of PPARβ/δ.
  • Kaupang, Åsmund; Bonge-Hansen, Tore. 2013. α-Bromodiazoacetamides – a new class of diazo compounds for catalyst-free, ambient temperature intramolecular C–H insertion reactions. Beilstein Journal of Organic Chemistry. 1407-1413.
  • Kaupang, Åsmund; Laitinen, Tuomo; Poso, Antti; Hansen, Trond Vidar. 2013. Vibrational fingerprinting of hPPARγ in complex with ligands – application to the natural product (-)-mucosin.
  • Gorbitz, Carl Henrik; Bonge-Hansen, Tore; Kaupang, Åsmund. 2013. N,N'-Bis(2-diazoacetyl)piperazine. Acta Crystallographica Section E: Structure Reports Online. o1241.
  • Kaupang, Åsmund; Laitinen, Tuomo; Vik, Anders; Poso, Antti; Hansen, Trond Vidar. 2013. Molecular modelling and synthesis of putative high-affinity inhibitors of hPPARδ.
  • Kaupang, Åsmund; Gorbitz, Carl Henrik; Bonge-Hansen, Tore. 2013. A solid-state oxidation of 1,1,3,3-tetramethylguanidinium 4-methylbenzenesulfinate to 1,1,3,3-tetramethylguanidinium 4-methylbenzenesulfonate. Acta Crystallographica Section C: Crystal Structure Communications. 778-+.
  • Kaupang, Åsmund; Gorbitz, Carl Henrik; Hansen, Tore. 2011. 2-Diazo-1-(1,1-dioxothiomorpholin-4-yl)ethanone. Acta Crystallographica Section E: Structure Reports Online. O1844-U2037.
  • Kaupang, Åsmund; Gorbitz, Carl Henrik; Hansen, Tore. 2010. tert-Butyl 4-(2-diazoacetyl)piperazine-1-carboxylate. Acta Crystallographica Section E: Structure Reports Online. O2199-U467.
  • Kaupang, Åsmund; Bolsones, M; Gamadeku, T; Hansen, Tore; Hennum, MJ; Gorbitz, Carl Henrik. 2008. 2SR,3RS)-Benzyl[4-chloro-1-(4-chlorophenyl)-1-methoxycarbonyl-2-butyl]ammonium chloride. Acta Crystallographica Section E: Structure Reports Online. O2038-U4798.

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