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  • E-mailJohan.Ferno@uib.no
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen

Dr. Fernø focuses on the link between obesity-induced inflammation and insulin resistance, in particular inflammatory signaling in the adipose tissue. In healthy individuals, adipose tissue immune cells maintain metabolic homeostasis, whereas in the obese state, these immune cells may change to pro-inflammatory phenotypes that contributes to metabolic disturbances, such as insulin resistance, type 2 diabetes and cardiovascular disease. Fernø and his group is looking at immune cell composition in different human adipose tissue depots and perform phenotypic and functional assessments of adipocytes, pre-adipocytes and various immune cell types, including adipose tissue macrophages (ATMs), natural killer (NK) cells, and T-cells. The group also investigate how tissue immune cell makeup is related to systemic markers of inflammation and metabolic disease and how these effects may be sex-specific. Fernø also has a research interest in hypothalamic regulation of appetite how this is affected by psychopharmacological medication.

Academic article
  • Show author(s) 2021. Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. Diabetes.
  • Show author(s) 2021. Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. Diabetes.
  • Show author(s) 2019. Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 1-7.
  • Show author(s) 2019. Retained NK cell phenotype and functionality in non-alcoholic fatty liver disease. Frontiers in Immunology. 1-13.
  • Show author(s) 2019. Exciting advances in GPCR-based drugs discovery for treating metabolic disease and future perspectives. Expert Opinion on Drug Discovery. 421-431.
  • Show author(s) 2019. Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. Scientific Reports.
  • Show author(s) 2018. p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Nature Communications. 1-16.
  • Show author(s) 2018. mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol. Journal of Endocrinology. 177-186.
  • Show author(s) 2018. Plasma ANGPTL-4 is Associated with Obesity and Glucose Tolerance: Cross-Sectional and Longitudinal Findings. Molecular Nutrition & Food Research.
  • Show author(s) 2018. Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis. Molecular Metabolism. 132-143.
  • Show author(s) 2018. Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake. Neuropharmacology. 62-70.
  • Show author(s) 2018. Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. Cell reports. 413-423.e5.
  • Show author(s) 2017. Thyroid hormones induce browning of white fat. Journal of Endocrinology. 351-362.
  • Show author(s) 2017. Reduction of hypothalamic endoplasmic reticulum stress activates browning of white fat and ameliorates obesity. Diabetes. 87-99.
  • Show author(s) 2017. Hepatic p63 regulates steatosis via IKK?/ER stress. Nature Communications. 1-19.
  • Show author(s) 2017. Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery. Translational Research: The Journal of Laboratory and Clinical Medicine. 35-44.e4.
  • Show author(s) 2016. Uroguanylin action in the brain reduces weight gain in obese mice via different efferent autonomic pathways. Diabetes. 421-432.
  • Show author(s) 2016. Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone–induced liver damage through inflammation and endoplasmic reticulum stress. Hepatology. 1086-1104.
  • Show author(s) 2016. Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment. European Neuropsychopharmacology. 589-598.
  • Show author(s) 2016. Acute stimulation of brain mu opioid receptors inhibits glucose-stimulated insulin secretion via sympathetic innervation. Neuropharmacology. 322-332.
  • Show author(s) 2015. The brain and brown fat. Annals of Medicine. 150-168.
  • Show author(s) 2015. Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-COA and the thermogenic effect of hypothalamic AMPK inhibition in female rats. Endocrinology. 947-960.
  • Show author(s) 2015. Orexins (hypocretins) and energy balance: More than feeding. Molecular and Cellular Endocrinology. 17-26.
  • Show author(s) 2015. Olanzapine depot exposure in male rats: Dose-dependent lipogenic effects without concomitant weight gain. European Neuropsychopharmacology. 923-932.
  • Show author(s) 2015. Hypothalamic-autonomic control of energy homeostasis. Endocrine. 276-291.
  • Show author(s) 2014. Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects. International Journal of Neuropsychopharmacology. 91-104.
  • Show author(s) 2014. Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats. Endocrinology. 1679-1689.
  • Show author(s) 2014. GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK. Diabetes. 3346-3358.
  • Show author(s) 2013. Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research.
  • Show author(s) 2012. Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats. International Journal of Neuropsychopharmacology. 163-179.
  • Show author(s) 2012. Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase. Diabetes. 807-817.
  • Show author(s) 2012. Lipid-lowering effects of tetradecylthioacetic acid in antipsychotic-exposed, female rats: challenges with long-term treatment. PLOS ONE. 11 pages.
  • Show author(s) 2012. Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. Psychopharmacology. 783-794.
  • Show author(s) 2011. Olanzapine-induced hyperphagia and weight gain associate with crexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation. PLOS ONE. 9 pages.
  • Show author(s) 2011. Lithium differentially affects clock gene expression in serum-shocked NIH-3T3 cells. Journal of Psychopharmacology. 924-933.
  • Show author(s) 2011. Lipogenic effects of psychotropic drugs: focus on the SREBP system. Frontiers in Bioscience. 49-60.
  • Show author(s) 2011. Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia. Pharmacopsychiatry. 15-20.
  • Show author(s) 2010. Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples. Molecular Psychiatry. 463-472.
  • Show author(s) 2009. Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells. BMC Pharmacology.
  • Show author(s) 2009. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? Molecular Psychiatry. 308-317.
  • Show author(s) 2009. Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. Psychopharmacology. 73-84.
  • Show author(s) 2008. Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples. Molecular Psychiatry.
  • Show author(s) 2008. Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients. International Journal of Neuropsychopharmacology. 679-684.
  • Show author(s) 2008. Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients. International Journal of Neuropsychopharmacology. 679-684.
  • Show author(s) 2008. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: pertubation of SREBP-controlled lipogenesis in drug-realted metabolic adverse effects? Molecular Psychiatry. 308-317.
  • Show author(s) 2006. SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: Relevance for metabolic side-effects? Molecular and Cellular Biochemistry. 167-173.
  • Show author(s) 2006. Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs. BMC Neuroscience.
  • Show author(s) 2006. Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neuroscience Letters. 185-190.
  • Show author(s) 2005. Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? The Pharmacogenomics Journal. 298-304.
Editorial
  • Show author(s) 2013. Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research. 307-309.
Short communication
  • Show author(s) 2015. Lack of hypophagia in CB1 null mice is associated to decreased Hypothalamic POMC and CART. International Journal of Neuropsychopharmacology. 1-6.
Popular scientific article
  • Show author(s) 2017. GPR55 - en ny reseptor for behandling av metabolsk sykdom? BestPractice Diabetes.
Doctoral dissertation
  • Show author(s) 2007. Lipogenic effects of antipsychotic drugs in cultured cells and in rat.
Abstract
  • Show author(s) 2008. Effect of clozapine on memory function in the hippocampal lesion model of schizophrenia. International Journal of Neuropsychopharmacology. 261-261.
  • Show author(s) 2008. Differential effects of antipsychotic drugs on ATP-binding cassette type A1 (ABCA1) and apolipoprotein E (ApoE) gene expression in cultured cells. International Journal of Neuropsychopharmacology. 259-259.
  • Show author(s) 2007. Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients. Nordic Journal of Psychiatry. 501-501.
  • Show author(s) 2006. Antipsychotic and antidepressive drugs regulate the expression of apolipoprotein E. Nordic Journal of Psychiatry. 338-338.
Poster
  • Show author(s) 2014. SLC7A10, a novel adipocyte-enriched gene with a potential role in adipocyte differentiation.
Academic literature review
  • Show author(s) 2021. Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance. International Journal of Molecular Sciences. 1-11.
  • Show author(s) 2020. Recent Updates on Obesity Treatments: Available Drugs and Future Directions. Neuroscience. 215-239.
  • Show author(s) 2020. Ghrelin and liver disease. Reviews in endocrine and metabolic disorders (Print). 45-56.
  • Show author(s) 2019. Natural killer cells as sensors of adipose tissue stress. Trends in endocrinology and metabolism. 1-10.
  • Show author(s) 2019. Glucagon control on food intake and energy balance. International Journal of Molecular Sciences. 1-12.
  • Show author(s) 2017. Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance. Neuroendocrinology. 398-411.
  • Show author(s) 2017. Gpr55: A new promising target for metabolism? Journal of Molecular Endocrinology. R191-R202.
  • Show author(s) 2016. Contribution of adaptive thermogenesis to the hypothalamic regulation of energy balance. Biochemical Journal. 4063-4082.
  • Show author(s) 2015. What is the real relevance of endogenous ghrelin? Peptides. 1-6.
  • Show author(s) 2014. Hypothalamic mTOR: the rookie energy sensor. Current molecular medicine. 3-21.
  • Show author(s) 2014. Hypothalamic effects of thyroid hormones on metabolism. Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism. 703-712.
  • Show author(s) 2014. Cross-talk between SIRT1 and endocrine factors: Effects on energy homeostasis. Molecular and Cellular Endocrinology. 42-50.

More information in national current research information system (CRIStin)

  • Adipocyte natural killer (NK) cells - immunological mediators of obesity-induced insulin resistance (Helse Vest RHF 912135)
  • Identification of novel pro-inflammatory macrophages in adipose tissue asscoated with obesity-induced insulin resistance (Helse Vest RHF 912289).
  • The effect of inflammation and gender on clinical outcome after bariatric surgery (Helse Vest RHF F-12543)
  • ENAMEP - Exosomes as innovative Nanomedicine Approaches to reverse obesity and its MEtabolic and Psychotic complications with specific targeting of the hypothalamus (ERANET/NFR 310778 - INTFELLES)