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  • E-mailJohan.Ferno@uib.no
  • Visitor Address
    Haukeland universitetssykehus, Laboratoriebygget
  • Postal Address
    Postboks 7804
    5020 Bergen

Dr. Fernø focuses on the link between obesity-induced inflammation and insulin resistance, in particular inflammatory signaling in the adipose tissue. In healthy individuals, adipose tissue immune cells maintain metabolic homeostasis, whereas in the obese state, these immune cells may change to pro-inflammatory phenotypes that contributes to metabolic disturbances, such as insulin resistance, type 2 diabetes and cardiovascular disease. Fernø and his group is looking at immune cell composition in different human adipose tissue depots and perform phenotypic and functional assessments of adipocytes, pre-adipocytes and various immune cell types, including adipose tissue macrophages (ATMs), natural killer (NK) cells, and T-cells. The group also investigate how tissue immune cell makeup is related to systemic markers of inflammation and metabolic disease and how these effects may be sex-specific. Fernø also has a research interest in hypothalamic regulation of appetite how this is affected by psychopharmacological medication.

Academic article
  • 2019. Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 1-7.
  • 2019. Retained NK cell phenotype and functionality in non-alcoholic fatty liver disease. Frontiers in Immunology. 1-13.
  • 2019. Exciting advances in GPCR-based drugs discovery for treating metabolic disease and future perspectives. Expert Opinion on Drug Discovery. 421-431.
  • 2019. Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. Scientific Reports.
  • 2018. p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Nature Communications. 1-16.
  • 2018. mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol. Journal of Endocrinology. 177-186.
  • 2018. Plasma ANGPTL-4 is Associated with Obesity and Glucose Tolerance: Cross-Sectional and Longitudinal Findings. Molecular Nutrition & Food Research.
  • 2018. Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis. Molecular Metabolism. 132-143.
  • 2018. Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake. Neuropharmacology. 62-70.
  • 2018. Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. Cell reports. 413-423.e5.
  • 2017. Thyroid hormones induce browning of white fat. Journal of Endocrinology. 351-362.
  • 2017. Reduction of hypothalamic endoplasmic reticulum stress activates browning of white fat and ameliorates obesity. Diabetes. 87-99.
  • 2017. Hepatic p63 regulates steatosis via IKK?/ER stress. Nature Communications. 1-19.
  • 2017. Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery. Translational Research: The Journal of Laboratory and Clinical Medicine. 35-44.e4.
  • 2016. Uroguanylin action in the brain reduces weight gain in obese mice via different efferent autonomic pathways. Diabetes. 421-432.
  • 2016. Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone–induced liver damage through inflammation and endoplasmic reticulum stress. Hepatology. 1086-1104.
  • 2016. Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment. European Neuropsychopharmacology. 589-598.
  • 2016. Acute stimulation of brain mu opioid receptors inhibits glucose-stimulated insulin secretion via sympathetic innervation. Neuropharmacology. 322-332.
  • 2015. The brain and brown fat. Annals of Medicine. 150-168.
  • 2015. Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-COA and the thermogenic effect of hypothalamic AMPK inhibition in female rats. Endocrinology. 947-960.
  • 2015. Orexins (hypocretins) and energy balance: More than feeding. Molecular and Cellular Endocrinology. 17-26.
  • 2015. Olanzapine depot exposure in male rats: Dose-dependent lipogenic effects without concomitant weight gain. European Neuropsychopharmacology. 923-932.
  • 2015. Hypothalamic-autonomic control of energy homeostasis. Endocrine. 276-291.
  • 2014. Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects. International Journal of Neuropsychopharmacology. 91-104.
  • 2014. Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats. Endocrinology. 1679-1689.
  • 2014. GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK. Diabetes. 3346-3358.
  • 2013. Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research.
  • 2012. Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats. International Journal of Neuropsychopharmacology. 163-179.
  • 2012. Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase. Diabetes. 807-817.
  • 2012. Lipid-lowering effects of tetradecylthioacetic acid in antipsychotic-exposed, female rats: challenges with long-term treatment. PLOS ONE. 11 pages.
  • 2012. Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. Psychopharmacology. 783-794.
  • 2011. Olanzapine-induced hyperphagia and weight gain associate with crexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation. PLOS ONE. 9 pages.
  • 2011. Lithium differentially affects clock gene expression in serum-shocked NIH-3T3 cells. Journal of Psychopharmacology. 924-933.
  • 2011. Lipogenic effects of psychotropic drugs: focus on the SREBP system. Frontiers in Bioscience. 49-60.
  • 2011. Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia. Pharmacopsychiatry. 15-20.
  • 2010. Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples. Molecular Psychiatry. 463-472.
  • 2009. Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells. BMC Pharmacology.
  • 2009. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? Molecular Psychiatry. 308-317.
  • 2009. Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. Psychopharmacology. 73-84.
  • 2008. Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples. Molecular Psychiatry.
  • 2008. Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients. International Journal of Neuropsychopharmacology. 679-684.
  • 2008. Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients. International Journal of Neuropsychopharmacology. 679-684.
  • 2008. Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: pertubation of SREBP-controlled lipogenesis in drug-realted metabolic adverse effects? Molecular Psychiatry. 308-317.
  • 2006. SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: Relevance for metabolic side-effects? Molecular and Cellular Biochemistry. 167-173.
  • 2006. Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: Marked differences between various antipsychotic drugs. BMC Neuroscience.
  • 2006. Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neuroscience Letters. 185-190.
  • 2005. Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? The Pharmacogenomics Journal. 298-304.
Editorial
  • 2013. Antipsychotic-induced increase in lipid biosynthesis: activation through inhibition? Journal of Lipid Research. 307-309.
Short communication
  • 2015. Lack of hypophagia in CB1 null mice is associated to decreased Hypothalamic POMC and CART. International Journal of Neuropsychopharmacology. 1-6.
Popular scientific article
  • 2017. GPR55 - en ny reseptor for behandling av metabolsk sykdom? BestPractice Diabetes.
Doctoral dissertation
  • 2007. Lipogenic effects of antipsychotic drugs in cultured cells and in rat.
Abstract
  • 2008. Effect of clozapine on memory function in the hippocampal lesion model of schizophrenia. International Journal of Neuropsychopharmacology. 261-261.
  • 2008. Differential effects of antipsychotic drugs on ATP-binding cassette type A1 (ABCA1) and apolipoprotein E (ApoE) gene expression in cultured cells. International Journal of Neuropsychopharmacology. 259-259.
  • 2007. Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients. Nordic Journal of Psychiatry. 501-501.
  • 2006. Antipsychotic and antidepressive drugs regulate the expression of apolipoprotein E. Nordic Journal of Psychiatry. 338-338.
Poster
  • 2014. SLC7A10, a novel adipocyte-enriched gene with a potential role in adipocyte differentiation.
Academic literature review
  • 2020. Ghrelin and liver disease. 45-56.
  • 2019. Natural killer cells as sensors of adipose tissue stress. 1-10.
  • 2019. Glucagon control on food intake and energy balance. 1-12.
  • 2017. Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance. 398-411.
  • 2017. Gpr55: A new promising target for metabolism? R191-R202.
  • 2016. Contribution of adaptive thermogenesis to the hypothalamic regulation of energy balance. 4063-4082.
  • 2015. What is the real relevance of endogenous ghrelin? 1-6.
  • 2014. Hypothalamic mTOR: the rookie energy sensor. 3-21.
  • 2014. Hypothalamic effects of thyroid hormones on metabolism. 703-712.
  • 2014. Cross-talk between SIRT1 and endocrine factors: Effects on energy homeostasis. 42-50.

More information in national current research information system (CRIStin)

  • Adipocyte natural killer (NK) cells - immunological mediators of obesity-induced insulin resistance (Helse Vest RHF 912135)
  • Identification of novel pro-inflammatory macrophages in adipose tissue asscoated with obesity-induced insulin resistance (Helse Vest RHF 912289).
  • The effect of inflammation and gender on clinical outcome after bariatric surgery (Helse Vest RHF F-12543)
  • ENAMEP - Exosomes as innovative Nanomedicine Approaches to reverse obesity and its MEtabolic and Psychotic complications with specific targeting of the hypothalamus (ERANET/NFR 310778 - INTFELLES)