ETECvac: Development of a vaccine for enterotoxigenic E. coli based on the heat-stable toxin
Enterotoxigenic E. coli (ETEC) expressing the heat-stable toxin (ST) is among the most important causes of diarrheal disease in children less than 5 years of age in low- and middle-income countries. Diarrhea causes ill health and malnutrition, and is the second most common cause of death among children. Currently available prototype ETEC vaccines target colonization factors and the heat-labile toxin, but not ST. They have so far failed to confer adequate protection, and development of an ST-based vaccine has a high priority.
The ETECvac project is based on a unique and comprehensive ST mutational library, established at the University of Bergen (UiB) and Uni Research, which allows an unprecedented detailed study of the toxin's properties. The main aims of the ETECvac project are to design safe and protective ST vaccine candidates, and to establish the first human challenge model for estimating the protective efficacy of an ST vaccine.
The research will be conducted at UiB and Uni Research, in close collaboration with partners at Institut Pasteur, Paris, France, and Indian Institute of Science, Bangalore, India.
- 2019. Virus-like particle-display of the enterotoxigenic Escherichia coli heat-stable toxoid STh-A14T elicits neutralizing antibodies in mice. Vaccine. 6405-6414.
- 2019. Immunizations with enterotoxigenic Escherichia coli heat-stable toxin conjugates engender toxin-neutralizing antibodies in mice that also cross-react with guanylin and uroguanylin. Infection and Immunity. 1-12.
- 2019. From potent toxin to vaccine toxoid: Engineering the enterotoxigenic Escherichia coli heat-stable toxin into a subunit vaccine component.
- 2018. Towards a heat-stable toxin-based subunit vaccine against enterotoxigenic E. coli.
- 2018. On the challenge of cysteine-rich peptide synthesis: the heat-stable toxin from Enterotoxigenic Escherichia coli (STh) and its toxoids .
- 2018. Mutational analysis of the pro-peptide of a marine intracellular subtilisin protease supports its role in inhibition. Proteins: Structure, Function, and Bioinformatics. 1-13.
- 2018. Modelling the chemical defensome networks --- a dynamic visualisation of the involved genes and interactions in two fish species and human.
- 2018. Modelling the chemical defensome network - a dynamic visualisation of the involved genes and pathways in two fish species and humans .
- 2018. Modelling The Chemical Defensome Networks - A Comparative Dynamic Visualisation Of The Involved Genes And Interactions In Two Fish Species And Humans.
- 2018. Independent losses of a xenobiotic receptor across teleost evolution. Scientific Reports. 1-13.